The 2^nd scientific meeting of the Foundation took place in the Hanover Medical school on May 12^th and 13^th 2011 before the 9th  ENCALS ( European Network for the Cure of ALS) meeting hosted by Pr Reinhard Dengler and Pr Susanne Petri.  A joint session took place on Friday with an invited speaker : Dr Philip A. Goliber, VP, Strategy and Portfolio at UCB . He  developed  the challenges of Pharma R&D and Drug Discovery in Orphan and Rare Diseases; a productive debate followed his lecture.

GRANTEES  2009 ET 2010 WITH THE MEMBERS OF THE SCIENTIFIC ADVISORY BOARD

Program of the meeting

Thursday 12 May

Presentations by grantees of round 2009:

 

• 14 h: Translational research into the role of the ephrin receptor EphA4 in the pathogenesis of ALS

Philip Van Damme

• 14.30 h: Pathological neuro-immune interactions between the macrophages/microglial cells and the affected motor neurons in animal models of ALS

Severine Boillée

• 15 h: Role of TDP43 in motor neurons through studying a unique Tdp43 mutant mouse

Elizabeth Fisher

• 15.30 h: Novel gene therapy approach for motoneuron disease through broad delivery of death signalling inhibitors by astrocytes

Cédric Raoul

• 16.30 h: Rescue of mitochondrial damage: new therapeutic strategies

Maria Teresa Carri

• 17 h: Contribution of Metabolic Dysfunction to ALS Pathogenesis

Jean-Philippe Loeffler

• 17.30 h: Role of the PGC-la system in the pathogenesis of ALS

Patrick Weydt

• 18 h: TLF: status and perspectives

V de Broglie, TLF director

 

Programme du Vendredi 13 Mai

 

Presentations by grantees of round 2010: 

 

• 8.30 h: Interplay between Androgenic/Anabolic Steroid and IGF-1 Signaling in Amyotrophic Lateral Sclerosis

Maria Pennuto

 

• 9 h : Utilization of features of the early disease phenotypes in a zebrafish model of ALS for pharmacological screening to detect small molecule neuroprotective compounds.

Tennore M Ramesh         

 

• 9.30h : Creation and characterization of in vitro and in vivo models to investigate the pathogenic mechanism of mutant FUS/TLS

Ludo Van Den Bosch      

 

• 10h : Functional characterization of two novel susceptibility loci in sporadic ALS

Jan H. Veldink      

 

• 11h : Human motor neurons derived from induced pluripotent stem (iPS) cells: a new approach for modeling and treating human sporadic ALS

Delphine Bohl

Year 1 of 2

 

• 11.30h :  G-CSF in ALS: from mice to humans

Caterina Bendotti

Year 1 of 1

 

• 12h : Modeling ALS with patient-derived pluripotent stem cells

Niels Geijsen

Year 1 of 1

 

• 12.30h : Restoration of respiratory motor function through optogenetics neural implants

Ivo Lieberam