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Role of the motor cortical area in ALS

Results making a significant contribution to understand the mechanisms of ALS neurodegeneration, and may providing insights to identify new targets for possible therapeutic manipulations Following the project selected in 2011 by the Thierry Latran Foundation : What is the...

Destruction of motor neurons

Several cellular mechanisms are suspected of causing the destruction of motor neurons Excitotoxicity: a mechanism of alteration and destruction of neurons by an excitatory substance called glutamic acid, present in the body. This mechanism is linked to a certain...

Epidemiology and Genetics

ALS generally appears between the ages of 40 and 70, but can also affect adults older or younger and, in rare cases, adolescents. Compared to other neurodegenerative diseases, the number of victims at a given moment in a given...

Biomarkers in ALS – June 2011

Interest and development of biomarkers in Amyotrophic Lateral Sclerosis The Thierry Latran Foundation is pleased to make available scientific information written and selected by Committee of French neurologists that we strongly thank for their support to the Foundation. NB:...

ALS treatment

Riluzole is the only therapy to have proven any efficacy. Studied since 1996, its efficacy remains moderate with an increase in survival time counted in months. Therefore, treatment is essentially symptomatic: Physiotherapy and occupational therapy (including specific equipment designed...

Symptoms

The onset of ALS is often very subtle, so that the symptoms may initially be overlooked. The earliest symptoms are muscle weakness and/or muscle atrophy. ALS does not usually present itself in a rough manner; the first symptoms, often...